Center for Humane Technology - clear effects, documented by relatively unbiased researchers and writers

Curable - An app for people living with chronic pain, a condition known to cause suicidal thinking.

Kognito - Kognito role-play simulations enable organizations to rapidly build the capacity of educators and students to lead real-life conversations that change lives

Objective Zero “enhances social connectedness and access to wellness resources to combat suicide within the military community.”

SuperBetter “builds resilience - the ability to stay strong, motivated and optimistic even in the face of change and difficult challenges.”

Tetris for PTSD - “The computer game Tetris can suppress flashbacks.”

UAMS Research study offers hope for anxiety and depression sufferers

Here are a couple of research videos about the health benefits of gaming & apps and also commentary on how mainstream developers work to gain market share regardless of value.